The discovery of neurogenesis and neural stem cells (NSC) in the adult CNS has overturned a long‐standing and deep‐routed “dogma” in neuroscience, established at the beginning of the 20th century. This dogma lasted for almost 90 years and died hard when NSC were finally isolated from the adult mouse brain. The scepticism in accepting adult neurogenesis has now turned into a rush to find applications to alleviate or cure the devastating diseases that affect the CNS. Here we highlight a number (...) of methodological, technical and conceptual drawbacks responsible for the historical denial of adult neurogenesis. Furthermore, we discuss old and new issues that need to be faced before NSC or endogenous neurogenesis can safely enter into the doctor's bag for therapies. BioEssays 30:135–145, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

In the mammalian brain dopamine systems play a central role in the control of movement, hormone release, emotional balance and reward. Alteration of dopaminergic neurotransmission is involved in Parkinson's disease and other movement disorders, as well as in some psychotic syndromes. This review summarises recent findings, which shed some light on signals and cellular interactions involved in the specification and maturation of the dopaminergic function during neurogenesis. In particular we will focus on three major issues: (1) the differentiation of dopaminergic (...) neurones triggered by direct contact with the midbrain floor plate cells through the action of sonic hedgehog; (2) the neurotrophic factors acting on dopaminergic neurones; and (3) the role of target striatal cells on the survival and the axonal growth of developing or grafted dopaminergic neurones. (shrink)

The extracellular‐signal regulated kinases 1/2 (ERK or ERKs) are involved in the regulation of important neuronal functions, including neuronal plasticity in normal and pathological conditions. We present findings that support the notion that the kinetics and localization of ERK are intrinsically linked, in that the duration of ERK activation dictates its subcellular compartmentalization and/or trafficking. The latter, in turn, dictates whether ERK‐expressing cells would enter a program of cell death, survival or differentiation. We summarize experimental data showing that chronic activation (...) of ERK plays a role in the mechanisms that trigger neurodegeneration. We also discuss how MKPs, members of the subclass of dual specificity phosphatases, might be the link between ERK kinetics and its subcellular localization. BioEssays 25:1085–1095, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

Despite that it is commonly accepted that migraine is a disorder of the nervous system with a prominent genetic basis, it is comorbid with a plethora of medical conditions. Several studies have found bidirectional comorbidity between migraine and different disorders including neurological, psychiatric, cardio- and cerebrovascular, gastrointestinal, metaboloendocrine, and immunological conditions. Each of these has its own genetic load and shares some common characteristics with migraine. The bidirectional mechanisms that are likely to underlie this extensive comorbidity between migraine and other (...) diseases are manifold. Comorbid pathologies can induce and promote thalamocortical network dysexcitability, multi-organ transient or persistent pro-inflammatory state, and disproportionate energetic needs in a variable combination, which in turn may be causative mechanisms of the activation of an ample defensive system with includes the trigeminovascular system in conjunction with the neuroendocrine hypothalamic system. This strategy is designed to maintain brain homeostasis by regulating homeostatic needs, such as normal subcortico-cortical excitability, energy balance, osmoregulation, and emotional response. In this light, the treatment of migraine should always involves a multidisciplinary approach, aimed at identifying and, if necessary, eliminating possible risk and comorbidity factors. (shrink)

The Calcolo geometrico (1888) seems to have been a turning point in the scientific career of Giuseppe Peano (1858?1932) because with this book he started publishing in logic. Looking for motivations of his early interests in the field one is naturally led to investigate the background of that book. Besides his previous work in mathematical analysis, methods and results of some Italian mathematicians and?above all?the spread of Grassmann's theories in Italy played a significant role: this point seems to have been (...) often underestimated by the historians of the subject. The connections between Calcolo geometrico and other related areas are also discussed. Peano's handwritten remarks and references taken from his own working copy of the Calcolo geometrico constitute the appendix of the paper. ?Simbolismo da alas ad mente de homo? (Peano 1913, 390). (shrink)

Antonio Rosmini is considered by many to be greatest Italian - or even European - thinker of the nineteenth century. But for christians he is also a saint. Here, marking ten years since his beatification in 2007, is an updated biography.

La conoscenza che abbiamo del testo del Libellus ad Leonem X, noto anche come De Officio Pontificis ad Leonem X, redatto dai camaldolesi veneziani Tommaso Giustiniani e Vincenzo Querini , ruota intorno al codice che “extabat MS in Bibliotheca Monasterii S. Mariae Carcerum, nunc in Bibliotheca S. Michaelis Muriani”1 identificabile con il manoscritto Muraniano 1071, oggi conservato presso la Biblioteca del Monastero di Camaldoli.2 Si tratta del codice che è stato utilizzato, secondo quanto dichiarato dallo stesso Mittarelli,3 dai camaldolesi Giovanni (...) Benedetto Mittarelli e Anselmo Costadoni 4 per la loro edizione negli Annales Camaldulenses.5 Vi è una notazione .. (shrink)

La crisi dello strutturalismo e i confini della semiotica in un volume importante della produzione di Eco. Un libro che trova la sua continuazione ideale in 'Lector in fabula'.